منابع مشابه
The TPP Is Dead, Long Live the TPP? A Response to Recent Commentaries
*Correspondence to: Ronald Labonté, Email: [email protected] Copyright: © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original...
متن کاملEvolution of the TPP - dependent enzyme family
The evolutionary relationships of the thiamine pyrophosphate (TPP) dependent family of enzymes was investigated by generation of a neighbor joining (NJ) phylogenetic tree using sequences from the conserved pyrophosphate (PP) and pyrimidine (Pyr) binding domains of 17 TPP-dependent enzymes. This represents the most comprehensive analysis of TPP-dependent enzyme evolution to date. The phylogeny w...
متن کاملIntroduction to the TPP package for analyzing Thermal Proteome Profiling data: 2D-TPP experiments
Thermal Proteome Profiling (TPP) combines the cellular thermal shift assay concept [1] with mass spectrometry based proteome-wide protein quantitation [2]. Thereby, drug-target interactions can be inferred from changes in the thermal stability of a protein upon drug binding, or upon downstream cellular regulatory events, in an unbiased manner. The package TPP facilitates this process by providi...
متن کاملExploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)
Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signal (MTS) in living cells. Here, we explored the hypothesis that TPP-related compounds could be utilized to inhibit mitochondria in cancer stem cells (CSCs). We randomly selected 9 TPP-related compounds for screening, using an ATP depletion assay. Based on this approach, five co...
متن کاملMitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy
Loss-of-function mutations in PINK1 or PARKIN are associated with early-onset Parkinson's disease. Upon mitochondrial stress, PINK1 and Parkin together mediate a response that protects cells from the accumulation of harmful, damaged mitochondria. PINK1, the upstream kinase accumulates on the mitochondrial surface and recruits the E3 ubiquitin ligase Parkin on site to ubiquitylate substrate prot...
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ژورنال
عنوان ژورنال: Perspectivas Revista de Ciencias Sociales
سال: 2018
ISSN: 2525-1112
DOI: 10.35305/prcs.v0i5.225